Dominique Guehl - Information to come
Dominique Guehl is a professor of physiology at the University of Bordeaux.
He’s neurologist and neurophysiologist, specialist of movement disorders, head of the clinical neurophysiology department for children and adults at the Bordeaux University Hospital. Member of the Parkinson’s disease expert center of the clinical Institute of Neurodegenerative Diseases.
He is a member of the « Physiology and Pathophysiology of Executive Functions » team located in the Institute of Neurodegenerative Diseases (CNRS UMR 5293; University of Bordeaux).
The cortico-striato-thalamo-loops (CSTCL) have been implacted in cortical rhythms, cognition, emotions, and motor behaviours. An alteration of their functioning can be at the origin of pathologies including psychiatric or mortor diseases. Here, we are propose to focus on motor loops using an electrophysiological approach in human and animal models of Parkinson’s disease.
This approach is complementary to the imaging one which studiez the Functionality Connectivity (FC) of the CSTCL.
We will discribe the electrophysiological properties of the constitutive structures of the basal ganglia by reporting data from single unit recordings and local field potentials performed in humans and animals.
We will see how a better knowledge of these electrophysiological activities can help us to understand the functioning of these motor loops in normal and pathological situations.